SARS-CoV-2 Infection Pathology in 45 Farmed Minks

45 minks from an infected farm were divided into four groups based on clinical health status and time of sampling: found dead before culling, clinically healthy during culling, showing clinical signs during culling, and found dead during culling. The dataset contains results from pathology, immunohistochemistry, virology, serology, and proteomics analyses, with over 57% of minks co-infected with Aleutian Disease Virus. It documents systemic viral spread and lung pathology even in asymptomatic animals.

Use Cases

• Analyze the correlation between clinical health status groups and the severity of interstitial pneumonia lesions.
• Investigate the distribution of viral antigen expression across respiratory and extra-respiratory tissues like the intestine, spleen, and lymph nodes.
• Compare viral RNA levels in nasal/throat swabs and nose/lung tissues against levels in the spleen, liver, and intestine.
• Assess the presence of SARS-CoV-2 specific antibodies across all four mink health status groups.
• Examine the co-infection rate with Aleutian Disease Virus (ADV) based on qPCR results.

Strengths

• Data is derived from a controlled study of 45 minks, providing a structured sample across four distinct health status groups.
• Includes multi-modal analysis covering pathology, virology, serology, and proteomics for a holistic view of infection.
• Findings are specific, reporting that over 57% of the studied minks were co-infected with Aleutian Disease Virus.

Limitations

• The sample size of 45 animals is small, limiting the statistical power for broad generalizations.
• The dataset's scope is limited to a single infected farm, which may not represent infection dynamics in all mink populations.
• Data format and specific column structure are unknown, which may complicate direct computational analysis.

Provenance

Source

Sandra Vreman via figshare.

Collection Method

Pathological, immunohistochemical, virological, serological, and proteomic analysis of minks from an infected farm.

Time Range

Associated with 2020 SARS-CoV-2 outbreaks in farmed minks.

Freshness

Last updated on 2026-03-24.

Geography

Netherlands.