Metabolomics-Guided Antiplasmodials in P. angulata with PfLDH Assay

A 2.7 MB PDF file from figshare, authored by Raden Bayu Indradi and last updated on 2026-04-23. It describes an integrated bioactivity-guided metabolomics approach to identify metabolites from P. angulata correlated with antiplasmodial activity, evaluated using a Plasmodium falciparum lactate dehydrogenase (PfLDH) assay, LC–MS profiling, and chemometric analysis.

Use Cases

• Identifying candidate anti-malarial metabolites based on bioactivity correlation from LC–MS data.
• Performing molecular docking simulations against parasite targets like PfLDH and PfDHFR using candidate metabolite structures.
• Developing chemometric models to link metabolite profiles with antiplasmodial activity measured by PfLDH assay.

Strengths

• Dataset is openly licensed under CC-BY-4.0.
• The description details a specific, multi-stage methodology integrating bioassay, LC–MS profiling, and molecular docking.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• The primary data file is a 2.7 MB PDF, which may contain processed results rather than raw data tables.

Provenance

Source

figshare

Collection Method

Bioactivity-guided metabolomics using PfLDH assay, LC–MS profiling, and chemometric analysis on P. angulata.

Freshness

Last updated 2026-04-23 10:04:32; freshness should be verified.