Supplementary Files for ACE Gene Hypertension Meta-Analysis

22 studies with 7,690 participants were analyzed for the association between the ACE (I/D) polymorphism and essential hypertension. This dataset contains the supplementary PDF files for the systematic review and meta-analysis, which found significant odds ratios for the D allele across multiple genetic models. The analysis covers diverse populations including Indian, European, African, Middle Eastern, and Hispanic groups.

Use Cases

• Extract genotype frequency data from the 22 included studies to recalculate pooled odds ratios for the ACE D allele.
• Analyze the subgroup results by ethnicity (Indian, European, African, etc.) to investigate population-specific genetic associations.
• Review the methodological details for the allelic, recessive, dominant, and homozygote genetic models applied in the meta-analysis.

Strengths

• Includes data from 7,690 participants (3,886 cases and 3,804 controls) across 22 studies.
• Provides detailed subgroup analysis by ethnicity, covering Indian, European, African, Middle Eastern, and Hispanic populations.
• Reports specific odds ratios with confidence intervals for four genetic models (allelic, recessive, dominant, homozygote).

Limitations

• The dataset is a 301.4 KB PDF file, limiting direct computational analysis and requiring manual data extraction.
• The meta-analysis includes studies from the last 20 years, which may incorporate older data with potentially outdated methodologies.
• Sample size for some ethnic subgroups (e.g., African, Middle Eastern) may be insufficient, as indicated by non-significant findings.

Provenance

Source

Athina Smallwood, via figshare.

Collection Method

Systematic review and meta-analysis of case-control and cohort studies from PubMed, Scopus, and Embase.

Time Range

Studies published within the 20 years prior to the article's publication.

Freshness

Last updated in March 2026, containing a review of studies from the preceding 20 years.

Geography

Global, with specific analysis of Indian, European, African, Middle Eastern, and Hispanic populations.