Supplementary information files for "Investigating the effects of post-exercise serum trea

Supplementary PDF files accompany a study investigating how serum collected after high-intensity exercise affects amyloid precursor protein processing in human iPSC-derived neurons and astrocytes. The data likely contains quantified markers of APP processing, including sAβPPα and Aβ₁–₄₂ levels, from cells treated with pre- and post-exercise serum. Author Richard J. Elsworthy published these files on figshare in April 2026 under a CC BY 4.0 license.

Use Cases

• Validate experimental findings on exercise-induced serum factors and ADAM10 activity based on the described biochemical assays.
• Analyze correlations between lactate, BDNF, IL-6 levels and AβPP processing markers mentioned in the study description.
• Compare APP processing responses between healthy control and familial AD (PSEN1 A246E) neural cell lines as described.
• Support meta-analyses on circulating factors that modulate pathways relevant to Alzheimer's disease pathology.

Strengths

• Data is directly linked to a peer-reviewed scientific study investigating a specific Alzheimer's disease mechanism.
• Files are published under a permissive CC BY 4.0 license, allowing for reuse and redistribution.
• The underlying study used a controlled experimental design with human iPSC-derived neurons and astrocytes.

Limitations

• The dataset is very small (186.0 KB), consisting only of supplementary PDF files, which limits direct computational analysis.
• Row count and column-level documentation are absent; data structure and variable semantics must be inferred from the PDFs.
• The specific numerical results and raw data tables are embedded within PDFs, requiring extraction for quantitative reuse.

Provenance

Source

figshare

Collection Method

Experimental data generated from treating human iPSC-derived neurons and astrocytes with pre- and post-exercise serum, followed by quantification of APP processing markers.

Freshness

Last updated 2026-04-28 08:27:19