Case Report: Acute MOGAD Myelitis in a Patient with Established Multiple Sclerosis

A 58-year-old woman with long-standing relapsing–remitting MS developed acute severe myelitis, a case documented by figshare admin karger in May 2026. Serum testing revealed high-titre MOG antibodies, and spinal MRI showed transient central grey matter involvement with an H-sign. This report highlights diagnostic challenges when distinguishing MOG antibody–associated disease from MS relapse.

Use Cases

• Study atypical clinical presentations of MS relapse based on the described case of acute myelitis with febrile prodrome.
• Analyze diagnostic markers for MOGAD based on features like serum antibody titres, CSF pleocytosis, and absence of oligoclonal bands.
• Train models to identify MRI features distinguishing MOGAD from MS based on the described H-sign on axial T2-weighted sequences.
• Investigate treatment responses in overlapping demyelinating disorders based on the patient's response to high-dose corticosteroids.

Strengths

• Detailed clinical timeline spanning over a decade of MS stability and an acute seven-day deterioration.
• Includes specific clinical scores (EDSS 6.0 to 8.0), lab results (CSF pleocytosis, elevated protein), and imaging findings (MRI H-sign).
• Documentation is provided in PDF and DOCX formats totaling 679.2 KB.

Limitations

• Data consists of a single case report; scale is extremely limited for statistical analysis.
• Column-level documentation is absent; field semantics must be inferred from the narrative description.
• Freshness should be verified; last updated 2026-05-16 07:55:09.

Provenance

Source

figshare admin karger

Collection Method

Clinical case documentation.

Freshness

Last updated 2026-05-16 07:55:09.