STELLAR: Real-World Safety and Efficacy Data for Lenvatinib vs. Sorafenib in Liver Cancer

STELLAR is a non-interventional, phase 4 study reporting final results on the safety and efficacy of lenvatinib versus sorafenib in patients with unresectable hepatocellular carcinoma. The dataset, published by figshare admin karger on April 24, 2026, includes data from 193 lenvatinib-treated patients and 123 sorafenib-treated patients from Western regions. It contains results on treatment duration, hepatotoxicity, adverse events, and overall survival.

Use Cases

• Compare real-world treatment duration and safety profiles between lenvatinib and sorafenib based on the reported cohort data.
• Analyze the incidence and types of hepatotoxicity treatment-emergent adverse events (TEAEs) described in the study results.
• Assess overall survival outcomes in a real-world patient population based on the reported median OS figures.
• Benchmark clinical trial efficacy findings against observational data from post-marketing studies.

Strengths

• Includes a direct comparator cohort of 123 sorafenib-treated patients as an internal reference group.
• Reports specific median treatment durations (6.5 months for lenvatinib, 4.4 months for sorafenib) and overall survival (16.9 months for lenvatinib).
• Provides detailed safety metrics, including the percentage of patients experiencing hepatotoxicity TEAEs (26.9% vs 33.3%).

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• The dataset is a 193.5 KB PDF, suggesting it contains summary results rather than raw, analyzable patient-level data.

Provenance

Source

figshare admin karger

Collection Method

Prospective, open-label, observational, phase 4 study (STELLAR) with data collected according to standard clinical practice at each site.

Time Range

Treatment duration ranged from 0.2 to 33.1 months for the cohorts studied.

Freshness

Last updated 2026-04-24 07:55:32; freshness should be verified.

Geography

Patients were from Western regions.