Anti-mGluR5 Encephalitis Case Report with Alzheimer's Biomarker Profile

A 2026 case report from figshare details a 51-year-old woman with rapidly progressive dementia. The document describes a clinical case of anti-mGluR5 autoimmune encephalitis initially misdiagnosed as Alzheimer's disease based on MRI/MRS and plasma biomarker findings. It highlights diagnostic challenges and the patient's response to immunotherapy.

Use Cases

• Study diagnostic overlap between autoimmune encephalitis and neurodegenerative disease based on the described biomarker profile.
• Analyze treatment-refractory dementia cases based on the clinical presentation and response to immunotherapy.
• Investigate the utility of specific plasma biomarkers (p-tau181, p-tau217, GFAP) in atypical dementia presentations.

Strengths

• Case report includes detailed clinical timeline over two years.
• Specific biomarker results (plasma p-tau181, p-tau217, GFAP) and imaging findings (MRI/MRS) are documented.
• License is CC-BY-4.0, permitting open sharing and adaptation.

Limitations

• Dataset is a single case report (25.0 KB DOCX), representing a sample size of one.
• Column-level documentation is absent; field semantics must be inferred after download.
• Data may reflect selection bias inherent to a single case study from figshare.

Provenance

Source

figshare admin karger

Collection Method

Published as supplementary material for a medical case report.

Freshness

Last updated 2026-04-22 05:55:16; freshness should be verified.