Supplementary Material: Cytokine Adsorption Therapy in Septic Shock with AKI

Supplementary Material for a retrospective cohort study of 73 adult patients with septic shock and acute kidney injury (AKI) treated with continuous veno-venous hemodiafiltration (CVVHDF). The dataset likely contains clinical variables used to evaluate the association between cytokine adsorption therapy and changes in SOFA score, in-hospital mortality, and hemodynamic trends. The study found cytokine adsorption was associated with a greater median ΔSOFA score and reduced mortality.

Use Cases

• Evaluating the association between cytokine adsorption therapy and 72-hour SOFA score changes based on treatment group and baseline characteristics.
• Modeling in-hospital mortality risk using multivariable logistic regression and Cox proportional hazards based on clinical and treatment variables.
• Conducting exploratory subgroup analyses on treatment response modifiers like membrane type and microbial profile.
• Assessing hemodynamic trends in patients with septic shock and AKI undergoing CVVHDF.

Strengths

• Dataset underpins a peer-reviewed medical study with specific, statistically significant results (e.g., median ΔSOFA 5.9 vs. 0.0, p<0.001).
• Analysis employed advanced statistical models with reported performance metrics (e.g., logistic regression ROC AUC = 0.930).
• Clearly defined patient cohort of 73 adults with septic shock and AKI undergoing a specific treatment (CVVHDF).

Limitations

• Column names and the exact number of rows are not provided in the available metadata, limiting understanding of the data structure.
• The study is a single-center retrospective cohort, which limits generalizability compared to a prospective multicenter trial.
• The dataset's primary content appears to be supplementary material (e.g., DOCX files), which may not be in an immediately analyzable tabular format.

Provenance

Source

figshare admin karger

Collection Method

Single-center retrospective cohort study.

Freshness

Last updated on 2026-03-19.