Supplementary Material for: Association of miR-335-5p Dysregulation with Postpartum Depres

A 167.7 KB Excel file containing supplementary data for a study on the association of microRNA miR-335-5p with postpartum depression (PPD). The data, made available by figshare admin karger under a CC-BY-4.0 license, includes clinical findings and experimental validation from a mouse model, last updated on 2026-05-25.

Use Cases

• Validate miR-335-5p as a diagnostic biomarker based on reported ROC curve analysis (AUC=0.862).
• Investigate correlations between miR-335-5p expression and sleep disorders in PPD patients based on described clinical correlations.
• Analyze the effects of miR-335-5p knockdown on depressive-like behaviors using data from the described mouse model.
• Study changes in oxidative stress markers (catalase, glutathione) and inflammatory factors (TNF-α, IL-6, IL-1β) following miR-335-5p inhibition.
• Explore target gene enrichment in circadian rhythm and MAPK signaling pathways based on the described GO and KEGG analyses.

Strengths

• Includes both human clinical data and experimental mouse model data, providing translational insights.
• Specific diagnostic accuracy metric reported for miR-335-5p (AUC=0.862).
• Data covers multiple analytical methods: RT-qPCR, ROC analysis, correlation tests, and enrichment analyses.

Limitations

• Row count and specific column definitions are unknown, requiring manual inspection after download.
• The dataset is small (167.7 KB), indicating limited scope and sample size.
• Description metadata is limited; actual data quality and completeness require verification.

Provenance

Source

figshare

Collection Method

Data likely generated from clinical measurements (RT-qPCR, ELISA) and controlled mouse model experiments as described.

Freshness

Last updated 2026-05-25 05:55:13.