RECAP-ICH: Protocol for Stroke Prevention Meta-Analysis

RECAP-ICH is a protocol document for an individual participant data meta-analysis of randomized controlled trials on blood pressure lowering for stroke prevention. The document outlines the methodology for pooling data from trials including TRIDENT, ESPRIT, PROGRESS, and RESPECT, focusing on patients with acute intracerebral hemorrhage. It was uploaded by figshare admin karger on May 25, 2026.

Use Cases

• Designing a meta-analysis workflow based on the described PRISMA-IPD systematic review methodology.
• Estimating time-to-benefit for blood pressure lowering therapies based on the described absolute risk reduction thresholds.
• Analyzing competing risks in clinical trial data based on the described sensitivity analysis treating death as a competing risk.
• Modeling cardiovascular event outcomes based on the described Cox proportional hazard model adjusting for age, sex, and history.

Strengths

• Protocol follows the PRISMA-IPD Statement, suggesting a structured methodological approach.
• Specifies inclusion criteria for trials enrolling at least 100 participants with intracerebral hemorrhage.
• Defines primary and secondary outcomes including time to first recurrent stroke and major adverse cardiovascular events (MACE).

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• The dataset is a 83.8 KB DOCX file, indicating a limited scope focused on the protocol document rather than raw trial data.

Provenance

Source

figshare admin karger

Collection Method

Protocol document for a planned meta-analysis pooling data from identified randomized controlled trials.

Freshness

Last updated 2026-05-25 05:55:09; freshness should be verified.