U.S. Hypothyroidism Cardiovascular Mortality Trends 1999-2020

382,906 cardiovascular disease deaths were linked to hypothyroidism over a 22-year U.S. national analysis. The dataset tracks age-adjusted mortality rates (AAMRs) per 100,000 population, revealing a peak of 10.12 in 2020 and disparities across gender, ethnicity, age, and rurality. It was compiled by researchers using CDC WONDER death certificate data and analyzed with Joinpoint regression.

Use Cases

• Analyze temporal trends in age-adjusted mortality rates (AAMRs) across demographic subgroups using 22 years of data.
• Compare mortality rate disparities between gender, ethnicity (Non-Hispanic White vs. Hispanic), and rural/urban residence categories.
• Model the annual percent change in mortality, such as the 14.01% increase observed between 2018 and 2020.
• Investigate the distribution of deaths by age cohort, focusing on the relative increases among adults aged 35–44 and 45–54 years.
• Examine the setting of death, as most occurred in long-term care facilities, for healthcare resource analysis.

Strengths

• Covers 22 years of national U.S. mortality data from 1999 to 2020.
• Based on 382,906 recorded cardiovascular disease deaths linked to hypothyroidism.
• Provides age-adjusted mortality rates (AAMRs) calculated per 100,000 using the 2000 U.S. standard population.
• Analyses reveal specific disparities across gender, ethnicity, age, and geography.

Limitations

• The 958.0 KB size suggests the dataset is a summary document, not the underlying raw record-level data.
• Sample data and column structure are unavailable, limiting direct analytical use without further processing.
• Findings are based on death certificate data, which can have limitations in diagnostic accuracy and coding consistency.

Provenance

Source

Centers for Disease Control and Prevention Wide-Ranging Online Data for Epidemiologic Research (CDC WONDER) database.

Collection Method

Death certificate data analysis using ICD-10 codes E02–E03 and I00–I99, with Joinpoint regression for temporal evaluation.

Time Range

1999 to 2020.

Freshness

Data covers through 2020, with metadata last updated in 2026.

Geography

United States, national level.