Voclosporin and Belimumab Treatment for Lupus Nephritis: 16-Patient Case Series

A retrospective case series of 16 female patients with biopsy-confirmed lupus nephritis treated between 2012 and 2025. The dataset, published by figshare admin karger, contains longitudinal clinical data including urine protein-to-creatinine ratio, serum creatinine, complement levels, and anti-dsDNA antibodies.

Use Cases

• Analyzing the reduction in proteinuria based on longitudinal urine protein-to-creatinine ratio data
• Evaluating serologic response to combination therapy based on C3, C4, and anti-dsDNA antibody levels
• Studying corticosteroid dose reduction patterns based on patient tapering outcomes mentioned in the description
• Assessing renal safety based on longitudinal serum creatinine measurements

Strengths

• Includes longitudinal data for 16 patients with a median follow-up period from 2012 to 2025
• Contains multiple validated clinical biomarkers: UPCR, serum creatinine, C3, C4, and anti-dsDNA
• Data is associated with a published clinical case series with specific statistical results (e.g., median UPCR decline from 2.175 to 0.082 g/g)

Limitations

• Row count is unknown, which may limit suitability assessment
• Column-level documentation is absent; field semantics must be inferred after download
• Data is from a single-center retrospective case series with a small sample size of 16 patients

Provenance

Source

figshare

Collection Method

Retrospective case series from routine clinical practice

Time Range

2012-2025

Freshness

Last updated 2026-04-28 07:55:21; freshness should be verified