Polygenic Scores for Sleep Traits and Lithium Response in Bipolar Disorder

European-ancestry data from 114 bipolar disorder patients categorized as lithium responders (N=79) or non-responders (N=35). The dataset contains polygenic scores for eight sleep-related traits, including chronotype and insomnia, used to evaluate associations with treatment response. The data was published by figshare admin karger on April 16, 2026.

Use Cases

• Replicate the association between polygenic scores for ease of getting up and lithium response based on the reported logistic regression models.
• Investigate potential interactions between different sleep-related polygenic scores mentioned in the description.
• Perform secondary analyses comparing extreme quartiles of polygenic scores for traits like chronotype and insomnia.
• Use the polygenic scores as features in predictive models for treatment outcome in bipolar disorder.

Strengths

• Includes polygenic scores for eight distinct sleep-related traits, as listed in the description.
• Reports a specific, statistically significant association for ease of getting up (OR=5.143, 95% CI=1.537–17.209).
• Data is openly available under a CC-BY-4.0 license.
• File size is 15.4 KB, indicating a compact and focused dataset.

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• Data is limited to 114 patients of European ancestry, which may limit generalizability.

Provenance

Source

figshare

Collection Method

Polygenic scores were calculated using PRS-CS from genetic data of 114 bipolar disorder patients.

Freshness

Last updated 2026-04-16 07:55:12; freshness should be verified.

Geography

Patients are of European ancestry.