miR-28-5p in Ischemic Stroke: Clinical and In Vitro Biomarker Data

Serum levels of microRNA miR-28-5p were measured in 129 ischemic stroke patients and 97 healthy controls, revealing its significant downregulation as a diagnostic and independent prognostic factor. The dataset likely contains clinical lipid profiles (TG, LDL-C, HDL-C), NIHSS scores, and in vitro results validating the miR-28-5p/WNK3 interaction's role in microglial polarization and inflammation. Its cross-platform presence signals importance for stroke biomarker and neuroprotection research.

Use Cases

• Prognostic modeling for stroke progression based on serum miR-28-5p levels and clinical covariates
• Analyzing correlations between miRNA expression and lipid profiles (TG, LDL-C, HDL-C) or stroke severity (NIHSS)
• Validating the miR-28-5p/WNK3 molecular pathway in microglial inflammation and oxidative stress models
• Biomarker discovery for distinguishing ischemic stroke patients from healthy controls

Strengths

• Includes data from a defined cohort of 226 total subjects (129 patients, 97 controls)
• Combines human clinical serum measurements with in vitro mechanistic validation data
• Released under a permissive CC-BY-4.0 license, facilitating reuse

Limitations

• Column names and exact row counts are not provided in the available metadata
• The dataset's temporal and geographic coverage for the patient cohort is unspecified
• Relies on inferred data types from the study description rather than explicit schema

Provenance

Source

Author listed as 'figshare admin karger'; specific institution not stated

Collection Method

Data generated via qRT-PCR for serum miRNA, Kaplan-Meier and COX regression for prognosis, and dual-luciferase/Oxygen-glucose deprivation (OGD/R) assays for mechanistic study

Time Range

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Freshness

Last updated on 2026-03-21

Geography

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