Case Report of Concurrent CML and CLL with Diagnostic and Treatment Details

A detailed clinical case report describes a rare instance of concurrent chronic myeloid leukemia and chronic lymphocytic leukemia in a single patient. The report includes diagnostic findings from blood tests, flow cytometry, cytogenetics, and molecular studies, as well as treatment response data over 14 months. The document was authored by a figshare admin for Karger and last updated in May 2026.

Use Cases

• Study diagnostic criteria for concurrent hematologic malignancies based on the integrated use of morphology, immunophenotyping, cytogenetics, and molecular studies described.
• Analyze treatment response and tolerability in a rare case based on the reported switch from imatinib to dasatinib and subsequent molecular response data.
• Review clinical presentation patterns based on the described symptoms of weight loss, back pain, and specific blood count abnormalities.
• Benchmark molecular response timelines based on the reported early molecular response at 3 months and major molecular response at 12 months.

Strengths

• The report provides a detailed, multi-method diagnostic workup including peripheral blood smear, flow cytometry, PCR, cytogenetics, and FISH.
• Includes specific treatment details (imatinib 400 mg daily, dasatinib 100 mg daily) and a 14-month follow-up with molecular response milestones.
• File size is 38.2 KB, indicating a concise, focused document.

Limitations

• Description metadata is limited; actual data quality requires manual inspection after download.
• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.

Provenance

Source

figshare admin karger

Collection Method

Likely a single clinical case study authored by medical professionals.

Freshness

Last updated 2026-05-13 05:55:28; freshness should be verified.