Supplementary Material for Dapagliflozin and Podocyte Injury in Diabetic Kidney Disease

Supplementary Material for a study on diabetic kidney disease (DKD) published on figshare. The study analyzed plasma lactate levels in 66 healthy controls, 150 patients with diabetes, and 152 patients with DKD, and investigated the protective effects of dapagliflozin in mice and cell cultures. The dataset was last updated on 2026-04 21.

Use Cases

• Analyzing correlations between plasma lactate levels and clinical markers like serum creatinine and albuminuria based on the human cohort data.
• Investigating the relationship between lactate accumulation and histone H4 lysine 12 lactylation (H4K12la) in podocytes based on the in vitro and in vivo experiments.
• Evaluating the potential renoprotective effects of dapagliflozin treatment on reducing lactate production and podocyte injury based on the study's results.

Strengths

• Includes data from a human cohort of 368 individuals (66 healthy, 150 diabetic, 152 DKD patients).
• Study design incorporates both retrospective human data and prospective in vivo/in vitro experiments.
• Released under a permissive CC-BY-4.0 license.

Limitations

• Dataset is very small at 25.5 KB, likely containing supplementary documents rather than primary data tables.
• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.

Provenance

Source

figshare admin karger

Collection Method

Retrospective analysis of patient data and experimental studies using db/db mice and cultured podocytes.

Time Range

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Freshness

Last updated 2026-04-21 05:55:46; freshness should be verified.

Geography

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