Clinical and Genetic Data for a Family with Early-Onset Diabetes

Supplementary materials from a 2026 study detail a digenic mechanism for early-onset diabetes in a single family. Author Makie Honda provides a clinical characteristics table and three figures analyzing genetic variants. The 1.2 MB dataset includes a pedigree chart and structural analyses of HNF1A and ABCC8 gene variants.

Use Cases

• Correlate clinical characteristics like age at onset and metabolic parameters with specific HNF1A and ABCC8 variants from Table S1.
• Analyze the pedigree structure in Figure S1 to understand inheritance patterns of digenic diabetes within a family.
• Use structural mapping in Figure S2 to assess the functional impact of HNF1A/HNF1B variants based on domain organization.
• Interpret protein contact analysis in Figure S3 to evaluate the mechanistic role of ABCC8 variants R298C and R521Q.

Strengths

• Data supports a specific, published mechanistic insight into digenic diabetes.
• Includes multi-modal analysis combining clinical table, pedigree, and protein structural figures.
• Released under a permissive CC-BY-4.0 license for reuse.

Limitations

• Extremely small sample size focused on a single family, limiting statistical power.
• Clinical data in Table S1 is not provided in a machine-readable tabular format (DOCX/PDF).
• No raw genetic sequencing data, only interpreted variant analyses.

Provenance

Source

figshare, associated with a specific research publication.

Collection Method

Clinical and genetic analysis of a studied family, compiled as supplementary material.

Freshness

Last updated in April 2026, indicating recent research.