Supplementary Material: Spatial Transcriptomic Profile of CD163+ Macrophages in VETC+ HCC

A 1.9 MB document containing supplementary material for a study on the tumor microenvironment in hepatocellular carcinoma. The material, uploaded by figshare admin karger on June 3, 2026, supports research characterizing pro-tumor macrophages in VETC+ HCC cases using spatial transcriptomics. It includes findings on specific gene upregulation and potential therapeutic targets.

Use Cases

• Validate gene expression signatures (e.g., SPP1, ACP5, GPNMB, FABP5) mentioned in the study for M2-like tumor-associated macrophages.
• Analyze pathways related to immunosuppression and angiogenesis described in the VETC+ HCC microenvironment.
• Correlate immunohistochemistry findings on SPP1 expression with spatial transcriptomic data discussed in the description.
• Identify potential therapeutic targets like SPP1 and ADAM9 for reshaping tumor-associated macrophages.

Strengths

• Data is openly licensed under CC-BY-4.0 for reuse and redistribution.
• The description provides specific biological context, gene names (SPP1, ADAM9, MMP9), and pathways of interest.

Limitations

• Row count and column-level documentation are absent; field semantics must be inferred after download.
• The dataset is small (1.9 MB) and consists of a DOCX file, which may limit the scale of quantitative analysis.
• Description metadata is limited; actual data quality requires manual inspection after download.

Provenance

Source

figshare

Collection Method

Likely contains supplementary data from a spatial transcriptomic study of hepatocellular carcinoma.

Freshness

Last updated 2026-06-03 07:55:14; freshness should be verified.