Lipid Metabolism Data from IL-13-Stimulated Nasal Organoids

Integrated transcriptomic and metabolomic profiles from a human apical-out nasal organoid model stimulated with IL-13. The dataset likely contains data from undifferentiated, mid-, and mature differentiation stages (Day 0, Day 7, Day 18). The supplementary material was uploaded by figshare admin karger and is licensed under CC-BY-4.0.

Use Cases

• Analyze dysregulation of fatty acid metabolism pathways based on gene expression data for uptake and elongation enzymes (CD36, ELOVL1/5/7)
• Investigate sphingolipid salvage synthesis activation based on metabolite levels and enzyme expression (CERS3/5, SGPP1/2)
• Model time-resolved metabolic changes during aberrant nasal epithelial differentiation based on data from three differentiation stages
• Validate multi-omics integration methods using paired transcriptomic and untargeted metabolomic profiles

Strengths

• Data is derived from an integrated multi-omics (RNA-seq and untargeted metabolomics) approach
• The model recapitulates a specific pathological phenotype (IL-13-induced aberrant nasal epithelial differentiation)
• The dataset includes time-resolved data from three distinct differentiation stages
• Files are available in common formats (DOCX, XLSX) totaling 6.7 MB

Limitations

• Column-level documentation is absent; field semantics must be inferred after download
• Row count is unknown, which may limit suitability assessment
• The description is specific to the study's biological findings; data structure details are not provided

Provenance

Source

figshare

Collection Method

Generated from an IL-13-stimulated human apical-out nasal organoid (hANO) model with integrated transcriptomic and metabolomic profiling.

Time Range

Data points correspond to Day 0, Day 7, and Day 18 of differentiation.

Freshness

Last updated 2026-04-27 09:55:11; freshness should be verified