Early Retinal OCTA Changes in Youth with Type 1 Diabetes, 2021-2023 Taiwan Study

Supplementary material for a 2021-2023 prospective case-control study from National Taiwan University Hospital investigating early retinal microvascular changes in children with type 1 diabetes. The study used optical coherence tomography angiography (OCTA) to detect clinically inapparent reductions in vessel density in the superficial and deep vascular plexuses. Findings propose a model sequence of retinal changes in T1DM, with data on 45.5 KB of DOCX files shared under a CC-BY-4.0 license.

Use Cases

• Modeling the sequence of early retinal changes in type 1 diabetes based on OCTA-derived vessel density and retinal thickness parameters.
• Analyzing the impact of prepubertal disease onset on the superficial capillary plexus in parafoveal and perifoveal areas.
• Correlating diabetes duration and glycosylated hemoglobin levels with microvascular alterations detectable by OCTA.
• Comparing macular vessel density in the superficial and deep vascular plexuses between pediatric T1DM patients and controls.

Strengths

• Prospective case-control design conducted at a single institution (National Taiwan University Hospital) from 2021 to 2023.
• Includes specific clinical metrics: average diabetes duration (5.0 ± 3.19 years) and average HbA1c level (7.41 ± 0.92%) for the T1DM group.
• Focuses on a specific, understudied population: children and youth with type 1 diabetes.

Limitations

• Row count and column-level documentation are absent; field semantics must be inferred after download.
• Data scale is limited to 45.5 KB, suggesting the files are likely supplementary documents rather than a primary dataset.
• Geographic coverage is limited to a single hospital in Taiwan, which may limit generalizability.

Provenance

Source

National Taiwan University Hospital (NTUH), Department of Ophthalmology and paediatric endocrinology clinic.

Collection Method

Prospective case-control study; patients and controls underwent comprehensive ophthalmological examinations and OCTA.

Time Range

2021 to 2023

Freshness

Last updated 2026-04-15 11:55:27; freshness should be verified.

Geography

Taiwan (National Taiwan University Hospital)