Efficacy of Ustekinumab on TNF-α Inhibitor-Induced Skin Reactions in IBD Patients

A study from June 2017 to September 2023 included 82 patients with Crohn's disease or ulcerative colitis who switched to ustekinumab due to skin reactions or secondary failure of TNF-α inhibitors. Authored by figshare admin karger and last updated in May 2026, the supplementary material analyzes skin reaction remission rates and long-term drug continuation using Kaplan–Meier and Cox models. The results indicate ustekinumab was effective for 95% of skin reactions without affecting long-term continuation.

Use Cases

• Analyze the efficacy of ustekinumab for skin reactions based on remission classifications (complete, partial, no response) described in the study.
• Model long-term drug continuation rates based on Kaplan–Meier survival analysis and Cox proportional hazards models mentioned in the methods.
• Investigate the association between psoriasiform dermatitis and TNF-α inhibitor use based on the reported 30% prevalence among skin reactions.
• Compare treatment outcomes between patient subgroups (skin reaction vs. non-skin reaction) using inverse probability of treatment weighting adjustments described.

Strengths

• Includes 82 patient records with specified counts for Crohn's disease (68) and ulcerative colitis (14).
• Reports a clear primary outcome measure: skin reaction efficacy classified into three distinct categories.
• Employs adjusted statistical methods, including inverse probability of treatment weighting (IPTW), to control for confounders.

Limitations

• Row count for the underlying data is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• Data may reflect single-hospital bias inherent to the source.

Provenance

Source

figshare admin karger

Collection Method

Retrospective study of patients at a single hospital who switched to ustekinumab.

Time Range

June 2017 to September 2023

Freshness

Last updated 2026-05-15 03:55:09; freshness should be verified.