Supplementary Material for Achalasia and Aspiration Pneumonia Study, 2016-2022

A retrospective single-center study of 70 patients diagnosed with achalasia between 2016 and 2022, comparing those with and without aspiration pneumonia. The dataset includes clinical symptom scores, esophagographic findings, high-resolution manometry parameters, and molecular analysis of esophageal mucosal biopsies. It was authored by figshare admin karger and last updated on 2026-04-24.

Use Cases

• Identify clinical risk factors for aspiration pneumonia based on patient age and disease duration.
• Analyze the relationship between symptom perception (Eckardt score) and aspiration risk.
• Investigate the role of mechanosensory/chemosensory channel expression (TRPV1, TRPV4, PIEZO1) in esophageal hyposensitivity.
• Compare high-resolution manometry and esophagographic subtypes between patient groups.

Strengths

• Includes data from 70 patients with achalasia, categorized into two groups (n=42 non-AP, n=28 AP).
• Uses propensity score matching to adjust for age and disease duration in a sub-cohort.
• Combines clinical, imaging, manometry, and molecular (qPCR) data modalities.

Limitations

• Row count and column-level documentation are absent; field semantics must be inferred after download.
• Data is from a single-center retrospective study, which may limit generalizability.
• The dataset is small (16.6 KB), indicating limited scope, likely containing supplementary document text rather than raw patient data.

Provenance

Source

figshare admin karger

Collection Method

Retrospective single-center study using high-resolution manometry, chest CT, esophagography, and qPCR analysis.

Time Range

2016-2022

Freshness

Last updated 2026-04-24 11:55:15; freshness should be verified.