Cognitive and Affective Outcomes After Centromedian Thalamus Neurostimulation

A retrospective analysis from a single institution evaluates neurocognitive and mood changes in 8 patients with drug-resistant epilepsy before and after responsive neurostimulation of the centromedian thalamus. The dataset, authored by figshare admin karger and last updated in April 2026, includes neuropsychological test results across nine functional domains over approximately 12 months. The supplementary material is provided as a 107.5 KB DOCX file.

Use Cases

• Analyzing changes in verbal learning and retrieval performance based on pre- and post-stimulation neuropsychological testing.
• Investigating the impact of thalamic stimulation on depression and anxiety metrics within a small patient cohort.
• Comparing cognitive domain outcomes, such as phonemic fluency and motor dexterity, following a specific neurosurgical intervention.

Strengths

• Data covers nine distinct neuropsychological functional domains, including attention, memory, fluency, and mood.
• Provides longitudinal pre- and post-operative data points for 8 patients over approximately 12 months.
• Includes specific clinical outcome metrics, such as the proportion of patients with clinically significant depression decreasing from 43% to 0%.

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• The cohort is small (8 patients), limiting statistical power and generalizability.

Provenance

Source

figshare

Collection Method

Retrospective analysis of patients who underwent responsive neurostimulation surgery at the authors' institution.

Time Range

Approximately 12-month follow-up period per patient.

Freshness

Last updated 2026-04 23:55:17; freshness should be verified.

Geography

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