Fatty Acid Biomarkers for Atrial Fibrillation Risk Analysis

Figshare hosts supplementary material for a study exploring the role of fatty acids, particularly palmitoleate, as a risk factor for atrial fibrillation. The material includes methodological details and results from a Mendelian randomization analysis and a cross-sectional study using gas chromatography-mass spectrometry. The dataset was uploaded by the figshare admin for Karger in April 2026.

Use Cases

• Validate Mendelian randomization findings linking specific fatty acids like palmitoleic acid to atrial fibrillation risk using detailed methodological protocols.
• Replicate gas chromatography-mass spectrometry (GC-MS) analysis procedures for quantifying serum levels of fatty acids such as stearic and α/γ-linolenic acid.
• Assess the diagnostic performance of palmitoleic acid levels as a biomarker, using reported area under the curve (0.727), sensitivity (100%), and specificity (50%) metrics.

Strengths

• Provides detailed methodological protocols for fatty acid extraction and methylation using the Methanol, n-hexane, MTBE method.
• Includes specific statistical results such as odds ratios (OR=1.35 for palmitoleic acid) and p-values (p=0.028) from the analysis.

Limitations

• The dataset is a 1.8 MB DOCX file containing supplementary material, not the primary raw or tabular data, limiting direct computational analysis.
• Sample size and specific row/column counts for the underlying patient cohort are not provided.

Provenance

Source

Figshare, uploaded by the figshare admin account for Karger.

Collection Method

Data derived from a cross-sectional study of hospitalized cardiology patients and a Mendelian randomization analysis; fatty acids were quantified via GC-MS.

Time Range

Patient enrollment occurred between May and June 2024.

Freshness

Last updated in April 2026, indicating recent maintenance.

Geography

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