Fetal Sylvian Fissure MRI Measurements for 324 Pregnancies, 22-38 Weeks Gestation

324 prenatal MRI scans from normal singleton pregnancies were used to quantify sylvian fissure development between 22 and 38+6 weeks of gestation. The study, published on figshare, established reference ranges for 10 morphological parameters like insula depth and sylvian fissure width. These normative charts successfully identified subtle cortical malformations in two genetically confirmed cases of polymicrogyria.

Use Cases

• Establish normative growth charts for fetal brain development based on sylvian fissure parameters.
• Train models for early detection of cortical malformations like polymicrogyria using MRI biometrics.
• Analyze left-right asymmetry in fetal brain structures based on measurements of sylvian fissure width and uncovered insula rate.
• Study correlations between gestational age and specific neuroanatomical features such as sylvian fissure depth.

Strengths

• Includes measurements from 324 normal singleton pregnancies, providing a substantial sample for normative modeling.
• High interobserver agreement was demonstrated, with intraclass correlation coefficients (ICC) ranging from 0.870 to 0.988.
• Parameters show strong correlation with gestational age, with |r| values up to 0.965.
• Clinical utility was validated by applying the charts to two confirmed cases of polymicrogyria.

Limitations

• Row count and column-level documentation are unknown, requiring manual inspection after download.
• The dataset is small in scale at 355.2 KB, limiting its direct use for large-scale machine learning.
• Data may reflect temporal and methodological bias inherent to the single retrospective study design.

Provenance

Source

figshare admin karger

Collection Method

Retrospective evaluation of prenatal MRI scans from a single study.

Time Range

Gestational ages 22 to 38+6 weeks.

Freshness

Last updated 2026-04-11 05:55:08; freshness should be verified.