Glomerular Structure and Function in Type 2 Diabetes Stratified by GBM Thickening

Supplementary material for a study analyzing glomerular structural-functional relationships in 30 people with type 2 diabetes. The research involved kidney biopsies, stereologic analyses, and stratification by glomerular basement membrane (GBM) thickness. The material was authored by figshare admin karger and last updated on 2026-05-21.

Use Cases

• Analyzing correlations between GBM thickening and clinical markers like HbA1c and albuminuria.
• Investigating relationships between mesangial matrix volume and eGFR slope in diabetic patients.
• Comparing renal structural phenotypes (e.g., hypertensive nephrosclerosis) in patients with and without GBM thickening.
• Identifying potential structural endpoints for clinical trials in type 2 diabetes kidney disease.

Strengths

• Includes stereologic analysis data from research kidney biopsies of 30 participants.
• Provides detailed stratification results, showing 21 of 30 participants had GBM thickening.
• Reports specific correlation coefficients (e.g., R=-0.5 for podocyte foot process width) with p-values.

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• The dataset is very small at 21.9 KB, indicating limited scope.

Provenance

Source

figshare admin karger

Collection Method

Research kidney biopsies and stereologic analyses performed on a cohort of 30 people with type 2 diabetes.

Freshness

Last updated 2026-05-21 09:55:20; freshness should be verified.