Familial Stroke Burden and Asymptomatic Brain Lesions in a Japanese Screening Cohort

60,310 stroke-free adults underwent brain health checkups in Tokyo, Japan, to assess the link between family history of stroke and subclinical cerebrovascular lesions. The study found that approximately 2% of participants had asymptomatic infarction and a similar proportion had cerebral microbleeds. The data, published under CC-BY-4.0, supports the analysis of biparental stroke history as a marker for increased subclinical burden.

Use Cases

• Train risk prediction models based on family history categories and demographic covariates.
• Analyze associations between biparental stroke history and MRI-detected asymptomatic infarction.
• Study the correlation between familial intracerebral hemorrhage history and cerebral microbleeds.
• Conduct secondary analyses on the interplay of family history with lifestyle and medical history variables.

Strengths

• Includes data from 60,310 participants, providing a substantial sample size.
• Analysis adjusted for multiple covariates including age, sex, BMI, smoking, and medical histories.
• Specific odds ratios with confidence intervals are reported for key associations.

Limitations

• The dataset is very small at 45.3 KB, suggesting it contains summary results or documentation rather than raw participant-level data.
• Row count and column-level documentation are unknown, limiting detailed assessment of the underlying data structure.
• Data is from a single center in Tokyo, which may limit generalizability to other populations.

Provenance

Source

figshare

Collection Method

Cross-sectional analysis of adults undergoing brain health checkups at a single center.

Freshness

Last updated 2026-04-25 05:55:15

Geography

Tokyo, Japan