LTT Performance Data: Impact of Cryopreservation and Processing Delays

30 patients and 30 gender-matched controls provided blood samples to assess the impact of processing delays and cryopreservation on the Lymphocyte Transformation Test. The study reports sensitivity and specificity metrics for detecting drug sensitization, with results published on figshare under a CC-BY-4.0 license. Data was last updated on April 21, 2026.

Use Cases

• Compare test performance metrics based on different PBMC processing methods described in the study.
• Analyze the impact of cryopreservation on interferon-y secretion levels as a read-out for drug sensitization.
• Validate laboratory protocols for handling blood samples when immediate processing is not possible.

Strengths

• Paired processing design where each patient and control served as its own reference, reducing individual variability.
• Reports specific sensitivity (45% vs. 31%) and specificity (81% vs. 79%) figures for different processing methods.
• Includes data from a cohort of 60 total participants (30 patients and 30 controls).

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• The 7.2 MB file size suggests a relatively small dataset.

Provenance

Source

figshare admin karger

Collection Method

Blood samples were split for paired processing, with IFN-γ concentrations measured by ELISA.

Freshness

Last updated 2026-04-21 05:55:44; freshness should be verified.