Arterial Stiffness Indices and p-tau217 Biomarker in 871 Mid-Life Women

871 community-dwelling mid-life women without dementia from Singapore's National University Hospital participated in this cross-sectional study. The dataset likely contains measurements of arterial stiffness indices (AIx, RI, CAVI) and the Alzheimer's disease blood biomarker p-tau217. Analysis by figshare admin karger in 2026 found associations between increased arterial stiffness and higher p-tau217 levels.

Use Cases

• Assess associations between arterial stiffness indices and Alzheimer's disease biomarkers based on p-tau217 measurements.
• Investigate vascular risk factors for tau pathology in a specific demographic based on data from non-demented mid-life women.
• Model the relationship between pressure wave reflection indices and neurodegenerative markers based on AIx and RI scores.
• Explore the role of post-menopausal estrogen deficiency in disease progression based on the study's participant cohort.

Strengths

• Includes data from 871 participants, providing a substantial sample size for analysis.
• Measures multiple indices of arterial stiffness (AIx, RI, CAVI) and a specific Alzheimer's biomarker (p-tau217).
• Analysis adjusted for multiple covariates including age, BMI, hypertension, and ApoE4 status.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• Data may reflect geographic bias inherent to a single hospital in Singapore.

Provenance

Source

Integrated Women’s Health Program (IWHP) at the National University Hospital, Singapore.

Collection Method

Cross-sectional analysis of participants attending routine health screening; blood biomarker measured via Simoa® assay.

Time Range

null

Freshness

Last updated 2026-04-30 07:55:08; freshness should be verified.

Geography

Singapore