Supplementary Material for Plk1 Inhibition in Obstructive Nephropathy

figshare admin karger published supplementary material for a study on Polo-like kinase 1 (Plk1) in obstructive nephropathy. The dataset includes TIF and DOC files totaling 45.2 MB, last updated on 2026-05-11. The research investigates the role of Plk1 in modulating renal water and sodium transporters using a unilateral ureteral obstruction model.

Use Cases

• Analyze protein expression patterns for aquaporin 2 (AQP2) and NKCC2 based on the described experimental results.
• Investigate the Plk1–cPLA₂–PGE₂–NEDD4/NEDD4L molecular pathway described in the study.
• Validate findings on pharmacological (BI6727) or genetic (heterozygous knockout) inhibition of Plk1 in kidney models.

Strengths

• Dataset size is explicitly stated as 45.2 MB.
• License is clearly defined as CC-BY-4.0.
• Last update timestamp is provided (2026-05-11 07:55:16).

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• Description metadata is limited; actual data quality requires manual inspection after download.

Provenance

Source

figshare admin karger

Collection Method

Supplementary material from a research study, likely containing experimental data and documentation.

Freshness

Last updated 2026-05-11 07:55:16; freshness should be verified.