Intracranial Arterial Calcification and Dementia Risk: Systematic Review and Meta-Analysis

Nine studies, including six cross-sectional and three longitudinal, were analyzed in a systematic review and meta-analysis investigating the link between intracranial arterial calcification on CT scans and cognitive impairment or dementia. The supplementary material, published under CC-BY-4.0 on figshare in April 2026, includes pooled odds ratios and hazard ratios from the quantitative synthesis. The file is a 2.5 MB DOCX document.

Use Cases

• Conducting secondary analyses on pooled effect measures (e.g., odds ratios) for calcification severity and dementia risk.
• Reviewing the methodology for systematic reviews linking neuroimaging biomarkers to clinical outcomes.
• Comparing associations between different calcification sites (e.g., vertebrobasilar vs. medial/IEL) and cognitive impairment.

Strengths

• Includes pooled quantitative results from nine distinct studies.
• Provides specific effect measures, such as a pooled adjusted odds ratio of 1.48 for the presence of calcification.
• Distinguishes between cross-sectional and longitudinal study designs and their respective findings.

Limitations

• Row count and column-level documentation are unknown, limiting suitability assessment.
• The data is supplementary material for a review; the primary, analyzable dataset is not provided.
• Description metadata is limited; actual data quality and structure require manual inspection after download.

Provenance

Source

figshare admin karger

Collection Method

Systematic review and meta-analysis of studies published before January 30, 2026.

Time Range

Studies published before January 30, 2026.

Freshness

Last updated 2026-04 15 11:55:23.

Geography

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