MIR205HG: Gene Expression Data for Calcium Oxalate Nephrolithiasis Study

62 upregulated and 17 downregulated genes were identified in this study of calcium oxalate nephrolithiasis. The dataset, published on figshare under a CC-BY-4.0 license, contains supplementary material analyzing the role of lncRNA MIR205HG and its interaction with miR-5581-3p and FSTL1. It includes experimental results from Randall's plaque tissues and COM-stimulated HK2 cells, last updated in May 2026.

Use Cases

• Validate gene expression patterns for MIR205HG, miR-5581-3p, and FSTL1 based on the described RT-qPCR and western blotting results.
• Study competitive endogenous RNA (ceRNA) regulatory networks in nephrolithiasis based on the described bioinformatics and luciferase assay findings.
• Analyze cellular responses like apoptosis, oxidative stress, and epithelial-mesenchymal transition (EMT) in kidney stone disease models based on the described assays.
• Replicate differential expression analysis based on the 62 upregulated and 17 downregulated genes identified in the study.

Strengths

• Includes data from both human Randall's plaque tissues and in vitro COM-stimulated HK2 cell models.
• Identifies a specific set of 62 upregulated and 17 downregulated genes.
• Provides supplementary files in PDF and XLSX formats totaling 4.1 MB.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• Data may reflect bias inherent to the specific experimental models and patient samples used.

Provenance

Source

figshare

Collection Method

Experimental data from RT-qPCR, western blotting, CCK-8, flow cytometry, and bioinformatics analysis of the GSE117518 dataset.

Freshness

Last updated 2026-05-14 05:55:15; freshness should be verified.