CYFRA 21-1 Meta-Analysis for Thyroid Cancer Lymph Node Diagnosis

Five studies comprising 533 patients and 681 lymph nodes were included in this systematic review and meta-analysis. The research, published by Karger via figshare in 2026, evaluates the diagnostic accuracy of the biomarker CYFRA 21-1 in fine-needle washout for detecting cervical lymph node metastases in differentiated thyroid carcinoma.

Use Cases

• Compare diagnostic performance of CYFRA 21-1 against fine-needle aspiration cytology (FNAC) based on pooled sensitivity and specificity metrics.
• Assess the complementary value of CYFRA 21-1 to thyroglobulin washout (FNA-Tg) in challenging clinical scenarios described in the review.
• Inform the design of future prospective studies on thyroid cancer diagnostics based on the analysis of evidence limitations and heterogeneity.

Strengths

• Analysis is based on a systematic review of five studies following PRISMA-DTA guidelines and registered in PROSPERO.
• The meta-analysis reports specific pooled performance metrics, including a sensitivity of 0.92 and a diagnostic odds ratio of 173.1.

Limitations

• The dataset consists of supplementary material files (PDF, DOCX); the underlying raw data tables are not provided.
• The evidence base is described as limited and heterogeneous, comprising only five studies.
• Row count and column-level documentation for any underlying data are unknown.

Provenance

Source

figshare

Collection Method

Systematic review and meta-analysis conducted according to PRISMA-DTA guidelines, searching PubMed, Scopus, and Cochrane Central.

Freshness

Last updated 2026-04-28 05:55:17