Women's Health Initiative Data on Migraine, Stroke, and Inflammatory Biomarkers

Supplementary material from a mediation analysis study investigating the role of inflammatory biomarkers in the link between migraine and stroke among postmenopausal women. The analysis uses data from 147,730 participants in the Women's Health Initiative, a large U.S. prospective cohort. The material was authored by figshare admin karger and updated in April 2026.

Use Cases

• Replicate mediation analysis models using hazard ratios (aHR) and confidence intervals (CI) for stroke outcomes associated with migraine history.
• Analyze associations between quartile-categorized biomarker levels (CRP, IL-6, TNF-α) and stroke risk using the provided hazard ratio estimates.
• Examine the reported proportions mediated (e.g., 3.98% for IL-6) to assess the biomarker's contribution to the migraine-stroke pathway.
• Validate spline-based Cox model findings for stroke risk across continuous levels of C-reactive protein, interleukin-6, and tumor necrosis factor-alpha.

Strengths

• Analysis based on a large cohort of 147,730 postmenopausal women from the Women's Health Initiative.
• Includes biomarker data subsets for CRP (n=43,754), TNF-α (n=10,610), and IL-6 (n=19,637).
• Provides specific statistical results including adjusted hazard ratios and 95% confidence intervals for multiple stroke types.

Limitations

• The dataset is small (1.2 MB) and appears to be supplementary documentation, not the underlying raw data.
• No direct access to patient-level columns or sample data is indicated, limiting analytical flexibility.
• Biomarker measurements are from baseline only, lacking longitudinal tracking.

Provenance

Source

Women's Health Initiative, a large U.S. prospective cohort of clinical trials and an observational study.

Collection Method

Prospective cohort analysis using Cox models, linear regression, and stabilized inverse probability weighting.

Time Range

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Freshness

Last updated in April 2026.

Geography

United States