Meta-Analytic Risk of Malignancy Estimates for Breast Cytopathology

Supplementary material for a meta-analysis of 22 studies on the IAC Yokohama System for breast fine-needle aspiration biopsy. The 1.1 MB document, authored by figshare admin karger and last updated in May 2026, presents a Bayesian reanalysis to calculate context-dependent risk of malignancy. It critiques standard pooled estimates and proposes reporting likelihood ratios or risk across a range of pretest probabilities.

Use Cases

• Evaluating the statistical validity of diagnostic meta-analyses based on the critique of pooled risk estimates.
• Applying Bayesian multinomial mixed effects models to diagnostic accuracy data based on the described methodology.
• Calculating post-test probabilities across varying disease prevalences based on the concept of category-specific likelihood ratios.
• Assessing the performance of the IAC Yokohama System for breast FNAB based on the reanalyzed data from 22 studies.

Strengths

• Document is 1.1 MB, indicating a detailed supplementary file.
• Analysis is based on a re-evaluation of 22 previously published studies.
• Applies a principled Bayesian workflow including convergence diagnostics and posterior predictive checks.
• Released under a permissive CC-BY-4.0 license.

Limitations

• The core data (columns, rows) are not directly accessible or described; the file is a DOCX document.
• Row count is unknown, which may limit suitability assessment.
• The 'inadequate' cytopathology category was excluded from the primary analysis.

Provenance

Source

figshare

Collection Method

Reanalysis of data from a previously published meta-analysis.

Freshness

Last updated 2026-05-12 07:55:30; freshness should be verified.