Case Report on Chlorprothixene Intoxication Managed with Plasma Exchange and Hemodialysis

A case report details the treatment of a 19-year-old female who ingested 5 grams of chlorprothixene. Serial sampling of serum, apheresis fluid, and dialysate was conducted to assess the quantitative impact of therapeutic plasma exchange and prolonged intermittent kidney replacement therapy on drug plasma levels. The report, authored by figshare admin karger and last updated in May 2026, concludes that extracorporeal removal of chlorprothixene was inconsequential.

Use Cases

• Analyze the pharmacokinetic impact of therapeutic plasma exchange based on serial serum sampling data mentioned in the description
• Evaluate the efficacy of high-flux hemodialysis for drug removal based on dialysate sampling data mentioned in the description
• Compare clinical outcomes in severe intoxication cases based on the patient's transfer timeline mentioned in the description

Strengths

• Detailed clinical timeline including specific drug dose (5g) and treatment volumes (5096 mL plasma exchanged)
• Explicitly states it is the first description of chlorprothixene intoxication managed with both therapeutic plasma exchange and high-flux hemodialysis

Limitations

• Data is presented as a single case report (n=1), limiting generalizability
• Column-level documentation is absent; field semantics must be inferred after download
• Row count is unknown, which may limit suitability assessment

Provenance

Source

figshare

Collection Method

Clinical case report documenting patient treatment and serial biological sampling.

Freshness

Last updated 2026-05-12 07:55:38; freshness should be verified