Nuclear YAP Expression in a Mouse Model of Fetal Lung Hypoplasia

139,730 bytes of supplementary material support a study investigating nuclear Yes-associated protein (nYAP) expression in an ex vivo mouse model of congenital diaphragmatic hernia (CDH) lung hypoplasia. The data includes quantitative gene expression results for markers like Ctgf and Cyr61, comparing fetal lungs with and without tracheal occlusion at the canalicular stage of development. This dataset provides underlying evidence for the role of mechanotransduction in fetal lung growth under hypoplastic conditions.

Use Cases

• Validating nYAP expression patterns in hypoplastic lung tissue based on immunohistochemistry results.
• Comparing Ctgf and Cyr61 gene expression levels between tracheal occlusion and control groups.
• Investigating the molecular response to mechanical stimulation in fetal lung development.
• Benchmarking results from an ex vivo nitrofen-induced CDH mouse model against other experimental systems.

Strengths

• Dataset is openly licensed under CC-BY-4.0, facilitating reuse and sharing.
• Data underpins a specific, peer-reviewed study with detailed methodological descriptions of the mouse model and interventions.
• Cross-platform presence on figshare indicates established curation and a signal of importance for the research community.

Limitations

• Column names and row counts are not provided, limiting understanding of the data's internal structure.
• The dataset consists of supplementary material in PDF format, which may not be in a directly machine-analyzable form.
• Metadata is sparse, lacking information on the organizing institution and specific data file composition.

Provenance

Source

figshare admin karger

Collection Method

Data generated from an ex vivo study using nitrofen-gavaged pregnant CD1 mice; fetal lungs harvested at E16.5 and cultured for 72 hours.

Time Range

Experimental observations from the canalicular stage of fetal mouse lung development (E16.5 + 3 days ex vivo culture).

Freshness

Last updated on 2026-03-19.