ENCHANTED Study: Early Neurological Deterioration Definitions and 90-Day Outcomes

Supplementary material from the ENCHANTED study, an international, multicenter trial examining definitions of early neurological deterioration (END) in thrombolysis-treated acute ischemic stroke patients. The dataset includes data from 4,434 patients and analyzes how different END definitions predict 90-day death or major disability and all-cause mortality. The material was uploaded by figshare admin karger and last updated on 2026-05-04.

Use Cases

• Comparing the predictive performance of different END definitions for 90-day functional outcomes based on NIHSS and GCS score changes.
• Training models to identify patients at higher risk of death or major disability based on early neurological deterioration events.
• Analyzing the association between END event frequency and 90-day odds ratios for unfavorable outcomes as described in the results.

Strengths

• Data originates from a large, international, multicenter randomized controlled trial (ENCHANTED) with 4,434 patients.
• Analysis includes specific, defined thresholds for neurological deterioration (e.g., NIHSS increase of ≥1, ≥2, ≥4 points).
• Results report concrete performance metrics, such as AUC values (e.g., 0.666 for 'any END') and odds ratios (e.g., OR 7.04).

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment for specific modeling tasks.
• Data files are in DOC/DOCX format (1.5 MB), which may require conversion for analysis.

Provenance

Source

Enhanced Control of Hypertension and Thrombolysis Stroke Study (ENCHANTED) trial.

Collection Method

International, multicenter, prospective, randomized open trial.

Freshness

Last updated 2026-05-04 05:55:19; freshness should be verified.

Geography

International (multicenter).