Case Series of Presumed Sterile Endophthalmitis Following Combined Intravitreal Therapy

Eight patients with chronic diabetic macular edema received intravitreal injections, with three developing severe presumed sterile endophthalmitis within 24 hours after combined triamcinolone and anti-VEGF therapy. This 244.9 KB PDF document, authored by figshare admin karger and last updated in April 2026, details the clinical presentation, management, and outcomes of these rare cases. Cultures from vitreous and medication vials were negative, supporting the sterile diagnosis.

Use Cases

• Analyze clinical presentation patterns based on described symptoms like severe pain, redness, and vision loss.
• Study treatment outcomes based on interventions like vitrectomy and intravitreal antibiotics with steroids.
• Investigate risk factors for sterile inflammation based on the combination of triamcinolone acetonide and anti-VEGF agents.
• Benchmark visual acuity recovery timelines based on final outcomes ranging from 6/9 to 6/12.

Strengths

• Case details include specific patient counts (8 total, 3 affected) and precise timing of symptom onset (within 24 hours).
• Clinical findings are described with high specificity, listing symptoms like lid edema, conjunctival congestion, and corneal edema.
• Outcomes are quantified with final visual acuity ranges (6/9–6/12) for treated patients.

Limitations

• Row count is unknown, which may limit suitability assessment for statistical analysis.
• Column-level documentation is absent; field semantics must be inferred after download.
• The dataset is a single 244.9 KB PDF, representing a very limited scope of a small case series.

Provenance

Source

figshare admin karger

Collection Method

Clinical case series from a single operative theatre setting.

Time Range

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Freshness

Last updated 2026-04-24 07:55:14; freshness should be verified.

Geography

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