Case Report: PGNMID with Severe Acute Kidney Injury Managed by Clone-Directed Therapy

A figshare-hosted case report describing a 60-year-old male patient with proliferative glomerulonephritis with monoclonal immunoglobulin deposits (PGNMID). The report details a relapse with severe acute kidney injury following viral enteritis and the subsequent successful treatment using daratumumab and bortezomib. The supplementary material, authored by 'figshare admin karger' and last updated in April 2026, is a 100.0 KB DOCX file.

Use Cases

• Analyzing clinical progression of PGNMID based on detailed case presentation including biopsy results and lab values.
• Studying treatment efficacy of clone-directed therapies like daratumumab and bortezomib for PGNMID without detectable clones.
• Investigating potential triggers for PGNMID relapse based on the reported association with viral enteritis.
• Reviewing diagnostic criteria and histopathological patterns for PGNMID as described in the biopsy findings.

Strengths

• Provides specific clinical metrics, including urine protein/creatinine ratios (UPCR) of 5.3 and 5.5 g/gCr, and serum creatinine of 11.0 mg/dL.
• Includes detailed histopathological findings from a second kidney biopsy.
• Released under a permissive CC-BY-4.0 license for reuse.

Limitations

• Row count and column-level documentation are unknown, limiting suitability assessment.
• The dataset is a single case report (100.0 KB), representing a very limited scope.
• The description metadata is limited; actual data content and structure require manual inspection after download.

Provenance

Source

figshare

Collection Method

Clinical case documentation.

Time Range

Case timeline spans approximately 2 years, as described in the report.

Freshness

Last updated 2026-04-15 07:55:33.

Geography

Patient location is not specified.