PRISM Study: Real-World Outcomes for 1,000 Japanese HCC Patients on Systemic Therapy

A prospective observational dataset of 1,000 patients with unresectable hepatocellular carcinoma (HCC) in Japan, collected between July 2020 and July 2022. The data includes demographics, tumor stage, liver function, treatment regimens, survival outcomes, and adverse events for first-line and subsequent therapies. It was created by the PRISM study group and published on figshare under a CC-BY-4.0 license.

Use Cases

• Compare real-world overall and progression-free survival for first-line HCC therapies based on reported median survival times.
• Analyze treatment sequencing patterns based on the description of second-line therapy usage.
• Assess the safety profiles of systemic therapies based on the reported rates of grade ≥3 adverse events.
• Evaluate objective response rates for different therapies using both RECIST v1.1 and mRECIST criteria mentioned in the description.

Strengths

• Data is from a nationwide, multicenter, prospective observational study with 1,000 enrolled patients.
• Includes detailed clinical outcomes such as median overall survival (21.8 months for Atezo+Bev) and progression-free survival.
• Reports objective response rates assessed by two standardized criteria (RECIST v1.1 and mRECIST).
• Captures real-world treatment patterns, including that approximately 50% of patients received second-line therapy.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count for the underlying data is unknown, which may limit suitability assessment.
• The dataset file is a 408.4 KB PPTX presentation, suggesting it may contain summary slides rather than raw patient-level data.

Provenance

Source

PRISM study group, published via figshare.

Collection Method

Nationwide, multicenter, prospective observational study with centrally monitored data collection.

Time Range

Patients enrolled between July 2020 and July 2022.

Freshness

Last updated 2026-05-21 09:55:11; freshness should be verified.

Geography

Japan