Risk Factors for Ischemic Stroke in Cold vs. Non-Cold China Regions Meta-Analysis

Supplementary material for a systematic review and meta-analysis of 96 studies involving 800,741 participants on ischemic stroke risk factors in China. The analysis, uploaded by figshare admin karger on April 15, 2026, compares pooled odds ratios for factors like atrial fibrillation and hypertension between cold and non-cold regions.

Use Cases

• Compare the strength of associations for hypertension with ischemic stroke between cold and non-cold regions based on the reported odds ratios.
• Analyze regional heterogeneity in the effect of diabetes mellitus on stroke risk based on the subgroup analysis results.
• Investigate the differential impact of lipid markers like triglycerides and LDL-C on stroke across climates as described in the findings.
• Examine the contrasting association of age with ischemic stroke in different regions based on the reported effect estimates.

Strengths

• Based on a systematic review of 96 studies, providing a broad evidence base.
• Includes data from 800,741 participants, offering a large sample size for meta-analysis.
• Provides specific pooled odds ratios with confidence intervals for multiple risk factors like atrial fibrillation (OR 4.48) and hypertension (OR 3.05).
• Conducts explicit subgroup analysis comparing cold versus non-cold regions in China.

Limitations

• Description metadata is limited; actual data quality requires manual inspection after download.
• Column-level documentation is absent; field semantics must be inferred after download.
• The data is presented as a PDF (7.2 MB), which may require extraction for computational analysis.

Provenance

Source

figshare admin karger

Collection Method

Systematic review and meta-analysis of observational studies from databases including PubMed, Embase, Web of Science, CNKI, Wanfang, VIP, and CBM.

Time Range

Studies from database inception through September 6, 2025.

Freshness

Last updated 2026-04 15 07:55:28; freshness should be verified.

Geography

China, with analysis split between cold and non-cold regions.