Case Report: Ruxolitinib-Associated Karyomegalic Interstitial Nephritis

figshare admin karger published a supplementary PDF document for a medical case report on 2026-05-13. The 793.8 KB file details the first reported case of karyomegalic interstitial nephritis (KIN) associated with a JAK inhibitor drug. It describes a patient's clinical presentation, biopsy findings, and outcome after drug withdrawal.

Use Cases

• Reviewing a detailed clinical case of drug-associated interstitial nephritis based on the described patient history and biopsy findings.
• Studying the potential for JAK inhibitors to cause DNA repair defects based on the proposed mechanism discussed in the conclusion.
• Identifying differential diagnoses for unexplained chronic interstitial nephropathy in patients on complex immunomodulatory therapies based on the case narrative.

Strengths

• The dataset is a 793.8 KB PDF file providing a complete case report.
• It documents the first reported association between KIN and JAK inhibitors, as stated in the conclusion.

Limitations

• The dataset is a single case report PDF; its scale is limited to one patient's data.
• Row count and column-level documentation are absent; data structure cannot be assessed from metadata.
• Description metadata is limited; actual data quality requires manual inspection after download.

Provenance

Source

figshare admin karger

Collection Method

Likely a published medical case report submitted as supplementary material.

Freshness

Last updated 2026-05-13 05:55:11; freshness should be verified.