LVR-R System: Safety and Feasibility in Severe Emphysema

Supplementary material for a first-in-human pilot study evaluating the Lung Volume Reduction Reverser (LVR-R) system in 15 patients with severe emphysema. Data includes pulmonary function tests, 6-minute walking distance, questionnaire scores, adverse events, and CT imaging from baseline to one-year follow-up. The study assessed technical feasibility and complication rates for the endoscopic coil implantation procedure.

Use Cases

• Evaluating procedural safety and adverse event rates based on recorded complications
• Analyzing changes in lung function metrics like FEV1 and residual volume over time
• Assessing patient-reported outcomes using CAT and mMRC questionnaire scores
• Comparing treatment response in walking capacity via 6-minute walking distance data
• Studying technical feasibility of coil implantation procedures in upper lobes

Strengths

• Data originates from a prospective, first-in-human clinical study with a defined protocol
• Includes longitudinal measurements from baseline to one-year follow-up for multiple outcomes
• Provides detailed counts of procedures (28), coil implantations, and adverse events

Limitations

• Column names and exact row count are not provided in the metadata
• Study cohort is small (15 patients), limiting statistical power
• Dataset consists of supplementary material; the primary data tables are not directly described

Provenance

Source

figshare admin karger

Collection Method

Prospective, nonrandomized, exploratory, single-center clinical study

Time Range

May 2019 to July 2022

Freshness

Last updated on 2026-03-24

Geography

Single-center study; location not specified