Sappanone A Effects on Diabetic Cardiomyopathy: In Vitro and In Vivo Experimental Data

1.9 MB of supplementary material for a study on Sappanone A's cardioprotective effects. The data, published under CC-BY-4.0 by figshare admin karger, includes results from in vitro H9c2 cardiomyocyte experiments and in vivo studies on STZ-induced diabetic cardiomyopathy mice. The dataset was last updated on 2026-05-08.

Use Cases

• Modeling the dose-response relationship of Sappanone A based on cell viability and apoptosis data mentioned in the description
• Analyzing correlations between autophagy markers (LC3-II/I, p62, LAMP1) and cardiac function parameters (ejection fraction, fibrosis) from the described experiments
• Validating TFEB-dependent mechanisms in diabetic cardiomyopathy using data from knockout models and chloroquine co-treatment described in the study

Strengths

• Includes both in vitro (H9c2 cardiomyocytes) and in vivo (STZ-induced DCM mice) experimental data, providing a multi-model perspective.
• Mechanistic validation is described using TFEB-knockout models and chloroquine co-treatment.
• Data is openly licensed under CC-BY-4.0.

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• Description metadata is limited; actual data quality requires manual inspection after download.

Provenance

Source

figshare

Collection Method

Experimental data from cell culture (H9c2 cardiomyocytes) and animal models (STZ-induced DCM mice).

Freshness

Last updated 2026-05-08 07:55:15; freshness should be verified.