Sex-Specific Clinical and Metabolic Profiles in Obstructive Sleep Apnea

A retrospective study of 1567 adults (1173 men, 394 women) from the Sleep Center of Zhongda Hospital, Southeast University, categorizes patients by OSA severity and healthy controls. The dataset contains demographic characteristics, blood routine results, metabolic panels, thyroid function tests, and comorbidity prevalence. It reveals significant sex dimorphism, with males showing progressive inflammation and metabolic dysregulation, while females present with atypical symptoms and thyroid hormone alterations linked to OSA severity.

Use Cases

• Comparing hematological markers (red blood cell counts, hematocrit, monocytes) by sex and OSA severity
• Analyzing metabolic profiles (dyslipidemia, glycosylated hemoglobin, uric acid) for male OSA patients
• Investigating thyroid hormone (free T3, free T4) alterations in female OSA patients
• Modeling comorbidity prevalence and demographic risk factors (smoking, alcohol use, snoring, insomnia) across sexes

Strengths

• Includes a substantial cohort of 1567 patients with explicit sex breakdown (1173 men, 394 women)
• Stratifies data by clinically defined OSA severity groups (mild, moderate, severe) and healthy controls
• Released under a permissive CC-BY-4.0 license, facilitating reuse and analysis

Limitations

• Column names and exact row count are not provided, limiting precise structural understanding
• Data is from a single-center retrospective study, which may limit generalizability
• The temporal coverage and specific collection dates are not stated

Provenance

Source

Sleep Center of Zhongda Hospital, Southeast University

Collection Method

Retrospective analysis of patient records

Time Range

null

Freshness

Last updated on 2026-03-19.

Geography

China (inferred from hospital location)