Supplementary Material for: Steroid Hormone Changes After Short-term High-Dose Exposure to

An exploratory study from the State of Florida Consortium for Medical Marijuana Clinical Outcomes Research evaluated plasma steroid hormones in 12 healthy participants. The randomized, placebo-controlled crossover trial administered oral cannabidiol (CBD) at 750 mg twice daily for 3.5 days, with plasma samples analyzed by LC–MS/MS. The dataset, last updated in 2026, provides preliminary evidence of CBD's modulation of the human steroidogenic system.

Use Cases

• Analyzing changes in 21-OH-progesterone, cortisol, corticosterone, and testosterone levels based on short-term high-dose CBD administration.
• Investigating correlations between hormone changes and CBD/metabolite concentrations as described in the study methods.
• Comparing hormonal responses between male and female subjects based on the reported sex-specific results for testosterone.
• Assessing the safety profile of CBD on endocrine function based on hormone levels remaining within physiological ranges.

Strengths

• Data originates from a randomized, placebo-controlled crossover study with 12 participants (6 males, 6 females).
• Hormone analysis was performed using LC–MS/MS, a precise measurement technique.
• The study design included a washout period and was supported by a named research consortium.

Limitations

• Row count and column-level documentation are unknown, limiting suitability assessment.
• The sample size of 12 participants is small, and the clinical significance of findings is described as uncertain.
• The primary data file is a 194.9 KB DOCX document, which is a tiny dataset and may contain summarized results rather than raw observations.

Provenance

Source

figshare admin karger

Collection Method

Plasma samples from a clinical trial were analyzed by LC–MS/MS.

Freshness

Last updated 2026-04-21 05:55:34