Surfactant-Budesonide Meta-Analysis for Preterm Infant Outcomes

Twenty-five studies involving over 5,700 preterm infants were analyzed to assess a combination therapy. This systematic review and meta-analysis, published on figshare in 2026, found moderate-certainty evidence that surfactant mixed with budesonide may reduce mortality and bronchopulmonary dysplasia. The analysis included randomized and observational studies searched from database inception to October 2025.

Use Cases

• Assessing treatment efficacy based on pooled risk ratios for mortality and BPD outcomes
• Evaluating the influence of study design on results based on the inclusion of both randomized and observational studies
• Investigating the role of prenatal steroid exposure based on its reported association with greater mortality reduction
• Comparing the effects of different surfactant types based on the analysis of bovine and porcine surfactant studies

Strengths

• Includes 25 studies with a total of 5,732 infants for the BPD outcome analysis
• Reports specific risk ratios with 95% confidence intervals (e.g., RR 0.83 for mortality)
• Assesses evidence certainty using the GRADE framework, resulting in a moderate rating for outcomes

Limitations

• The dataset is a 2.7 MB DOCX document; the underlying study data is not provided in a structured, machine-readable format
• Column-level documentation is absent; field semantics must be inferred after download
• Row count for the primary data is unknown, which may limit suitability assessment

Provenance

Source

figshare

Collection Method

Systematic review and meta-analysis of studies from PubMed, Scopus, and Web of Science.

Time Range

Studies searched from database inception to October 2025.

Freshness

Last updated 2026-04-25 05:55:24; freshness should be verified