Prolactin in Tuberculosis: Mouse Lung Gene Expression and Immunohistochemistry Data

245.7 KB of supplementary material from a study on prolactin's role in experimental pulmonary tuberculosis. The data includes RT-PCR gene expression and immunohistochemistry results from BALB/c mouse lungs infected with Mycobacterium tuberculosis H37Rv, collected by figshare admin karger and last updated in 2026. In vitro experiments on alveolar macrophages and type II pneumocytes are also described.

Use Cases

• Analyzing prolactin and prolactin receptor gene expression kinetics based on RT-PCR data from infected mouse lungs.
• Studying cellular localization of prolactin and its receptor based on immunohistochemistry staining patterns in lung tissue.
• Modeling the effects of prolactin treatment on bacterial load reduction based on in vivo bacillary load measurements.
• Investigating prolactin's impact on innate immune factors like reactive oxygen species and cathelicidin based on in vitro macrophage and pneumocyte experiments.

Strengths

• Data is openly licensed under CC-BY-4.0, permitting reuse and redistribution.
• The study design includes both in vivo (mouse model) and in vitro (cell lines) experimental data.
• Specific time points for data collection are mentioned, including early infection (first week) and progression up to four months.

Limitations

• Row count and column-level documentation are unknown, which may limit suitability assessment.
• The dataset is small (245.7 KB), indicating a limited scope of data.
• Description metadata is limited; actual data quality and structure require manual inspection after download.

Provenance

Source

figshare

Collection Method

Experimental data from BALB/c mice infected with Mycobacterium tuberculosis H37Rv, with gene expression quantified by RT-PCR and cellular expression assessed by immunohistochemistry.

Freshness

Last updated 2026-05-26 11:55:14; freshness should be verified.