Clinical Case Report and Literature Review on Topical Statins for Porokeratosis

A 63-year-old woman with refractory disseminated superficial actinic porokeratosis showed marked improvement after six months of treatment with compounded simvastatin 2% cream. This DOCX file contains a detailed case report and a review of 10 representative studies, including one randomised controlled trial, on the use of topical statins for this skin disorder. The supplementary material was authored by a figshare admin for Karger and last updated in April 2026.

Use Cases

• Analyzing treatment efficacy and relapse patterns based on the detailed case presentation.
• Reviewing evidence from clinical studies, including an RCT and a split-body study, mentioned in the literature review.
• Investigating the safety profile of topical statins based on reported adverse effects like local irritation and creatine kinase elevation.
• Studying the role of cholesterol co-formulation in treatment based on conflicting evidence discussed in the review.

Strengths

• Includes a detailed case report with a specific treatment regimen (simvastatin 2% cream twice daily) and six-month outcome.
• Literature review synthesizes evidence from 10 representative reports, including controlled studies.
• File is openly licensed under CC-BY-4.0 for reuse.

Limitations

• The 28.1 KB file size suggests limited scope, containing a single case report and review rather than a large dataset.
• Column-level documentation is absent; field semantics must be inferred after download as the data structure is unknown.
• The data is a supplementary document; its primary use is for reference rather than quantitative analysis.

Provenance

Source

figshare admin karger

Collection Method

Clinical case report and literature review compilation.

Time Range

Case report timeframe is unspecified; literature review covers studies up to the publication date.

Freshness

Last updated 2026-04-16 05:55:26

Geography

Geographic coverage of the case and reviewed literature is unspecified.